Heyy all!,
Time for the fortnightly weather update from Birmingham.... ;) Well now that I have began with it I might as well continue... the weather here is really pleasant (as in me and Chits seem to like it but the locals aren't as thrilled for some reason!), not at all humid and the rains seem to have stopped as of late... not that it rained much even when it did. I heard about the strong rains back in Mumbai and as always reporters standing in pits and commenting that the city is drowning blah blah..... but all of us being battle-hardened Indians, I can safely presume that all are safe and everyone's keeping well :)
Last Saturday we had been to Shakespeare's town... where he was born, he lived, he died (and whatever else he did inbetween... like making quotes 'What is in a name' and so on), then his mom's farmhouse and finally his girlfriend-turned-wife's place. Frankly, I don't even visit so many of my own relatives when I go to my hometown :p ... And we walked over half an hour to reach his girlfriend's place, I doubt I would bother as much for my own, if I had one ;) (interestingly her name is Anne Hathaway, one of my favorite hollywood ladies :D)
The place was no doubt very interesting... I am sure most of us would have come across the phrase "a cut above the rest" and "upper crust". Ever wondered how they originated, the phrases? Interestingly, in olden times when the ladies (so presumably Anne Hathaway in case of Shakespeare ;), made bread or other similar stuff in the house, it used to be baked in a small oven (nopes not microwave or grill ovens.... these were olden times, really old... so think of logs of wood and brick lined walls). So the bottom tended to have grit and charcoal,dirt etc which used to be in touch with the food being baked (no they didnt have microwave safe cookware for obvious reasons) and also the bottom used to turn out much harder to chew. So it was common to cut the bottom slices and give to the lesser members of the household and the cleaner, softer upper slices to the head of the house or any guest of higher standing. So the phrase basically refers to the dividing up of bread in a household where the elite got "a cut above the rest" :) Interesting, isn't it!
On Sunday, we were invited by Dr. Brain to a departmental get-together at the Head of Department's (newly announced - both the department, after re-structuring, and the HOD) place. We had booked tickets for Cadbury World for the afternoon but still decided to make it to the 'party' afterwards. The main intention obviously being to "meet people" (I am sure everyone follows ;). So we turned up at around 6PM, a couple of hours late. There were roughly 15 people left out of which, apart from us, only 3 were below the age of 30. To elaborate further - two of them were Dr. Brains kids and the third was the hosts son (who evidently was reluctantly a part of the party!). So that was that :p But yeah we did interact with several faculties, none of whom I can remember by name or face anymore (except maybe one or two).
As for the work, I am too bored to go in much detail.... except reinforce what I said last time that we are spending more time in the lab here, 'working' (important clause), than we did back in Mumbai! Trust me we are not on a vacation, so anyone greeting us when back with "Welcome from the break/vacation" will have their chocolates cut down by half! ;) But yeah jokes apart, the work is exciting and there is, might sound like a cliche, loads of new things to learn each day! From what we have discussed and planned ahead, I am sure there is enough to keep us occupied till we return and even then there would be several things we couldn't touch upon. We have certainly not forgotten about the pics, but keeping that for a bit later (dont ask me why, we just have not got down to doing it but will certainly take loads to show everyone).
Anyone read any of the papers by this guy called Hikaru Hashitani. Well this 'guy' happens to be a big-shot in the field of electrophysiology and according to Peter (the post-doc here) he is the master of sharp micro-electrode recordings and the best in the business. So the reason I brought up his name (not for random trivia), was that he happened to be in UK and Dr. Brain had taken him out for dinner one of the days. Peter was saying that the guy is known to have a sharp tongue and doesn't mince any words when commenting on anything. It felt different hearing about these 'authors' as people rather than mere names on the top of articles.
One of his papers, can't remember which one but its been widely discussed in the lab, has work on simultaneous contraction studies and electrophysiology (and in a couple of cases also imaging work). I had read through the paper before but hardly gave any thought to the experimental protocol and technique, nor imagined that it involved any level of complexity. But having had a chance to see first hand how these stuff are done, its nothing short of a miracle to obtain those kinds of recordings that he has produced in that paper (if indeed they are genuine :p - just kidding!).
Leaving the unpleasant for the last... this last week we had to endure the worst kind of racism and that too in the lab. This is how it began. Till the week before we had been using a kind of mice called C57/BL6. This week onwards we shifted to BAL B/C mice. And that's where the trouble began! For two days in a row we couldn't manage to get a single electrical recording despite trying from 10AM to 6PM! It just would not respond. And the only difference was this... the former were Black mice and these new ones were White! :p But yes we did finally get the better of them today and put them into place. Infact, we managed to get two of our most impressive recordings till date! :)
Thats all for now... this letter has turned out to be much longer than I had planned..... so till the next fortnightly update... Adios!
Cheers,
Shailesh Appukuttan
Time for the fortnightly weather update from Birmingham.... ;) Well now that I have began with it I might as well continue... the weather here is really pleasant (as in me and Chits seem to like it but the locals aren't as thrilled for some reason!), not at all humid and the rains seem to have stopped as of late... not that it rained much even when it did. I heard about the strong rains back in Mumbai and as always reporters standing in pits and commenting that the city is drowning blah blah..... but all of us being battle-hardened Indians, I can safely presume that all are safe and everyone's keeping well :)
Last Saturday we had been to Shakespeare's town... where he was born, he lived, he died (and whatever else he did inbetween... like making quotes 'What is in a name' and so on), then his mom's farmhouse and finally his girlfriend-turned-wife's place. Frankly, I don't even visit so many of my own relatives when I go to my hometown :p ... And we walked over half an hour to reach his girlfriend's place, I doubt I would bother as much for my own, if I had one ;) (interestingly her name is Anne Hathaway, one of my favorite hollywood ladies :D)
The place was no doubt very interesting... I am sure most of us would have come across the phrase "a cut above the rest" and "upper crust". Ever wondered how they originated, the phrases? Interestingly, in olden times when the ladies (so presumably Anne Hathaway in case of Shakespeare ;), made bread or other similar stuff in the house, it used to be baked in a small oven (nopes not microwave or grill ovens.... these were olden times, really old... so think of logs of wood and brick lined walls). So the bottom tended to have grit and charcoal,dirt etc which used to be in touch with the food being baked (no they didnt have microwave safe cookware for obvious reasons) and also the bottom used to turn out much harder to chew. So it was common to cut the bottom slices and give to the lesser members of the household and the cleaner, softer upper slices to the head of the house or any guest of higher standing. So the phrase basically refers to the dividing up of bread in a household where the elite got "a cut above the rest" :) Interesting, isn't it!
On Sunday, we were invited by Dr. Brain to a departmental get-together at the Head of Department's (newly announced - both the department, after re-structuring, and the HOD) place. We had booked tickets for Cadbury World for the afternoon but still decided to make it to the 'party' afterwards. The main intention obviously being to "meet people" (I am sure everyone follows ;). So we turned up at around 6PM, a couple of hours late. There were roughly 15 people left out of which, apart from us, only 3 were below the age of 30. To elaborate further - two of them were Dr. Brains kids and the third was the hosts son (who evidently was reluctantly a part of the party!). So that was that :p But yeah we did interact with several faculties, none of whom I can remember by name or face anymore (except maybe one or two).
As for the work, I am too bored to go in much detail.... except reinforce what I said last time that we are spending more time in the lab here, 'working' (important clause), than we did back in Mumbai! Trust me we are not on a vacation, so anyone greeting us when back with "Welcome from the break/vacation" will have their chocolates cut down by half! ;) But yeah jokes apart, the work is exciting and there is, might sound like a cliche, loads of new things to learn each day! From what we have discussed and planned ahead, I am sure there is enough to keep us occupied till we return and even then there would be several things we couldn't touch upon. We have certainly not forgotten about the pics, but keeping that for a bit later (dont ask me why, we just have not got down to doing it but will certainly take loads to show everyone).
Anyone read any of the papers by this guy called Hikaru Hashitani. Well this 'guy' happens to be a big-shot in the field of electrophysiology and according to Peter (the post-doc here) he is the master of sharp micro-electrode recordings and the best in the business. So the reason I brought up his name (not for random trivia), was that he happened to be in UK and Dr. Brain had taken him out for dinner one of the days. Peter was saying that the guy is known to have a sharp tongue and doesn't mince any words when commenting on anything. It felt different hearing about these 'authors' as people rather than mere names on the top of articles.
One of his papers, can't remember which one but its been widely discussed in the lab, has work on simultaneous contraction studies and electrophysiology (and in a couple of cases also imaging work). I had read through the paper before but hardly gave any thought to the experimental protocol and technique, nor imagined that it involved any level of complexity. But having had a chance to see first hand how these stuff are done, its nothing short of a miracle to obtain those kinds of recordings that he has produced in that paper (if indeed they are genuine :p - just kidding!).
Leaving the unpleasant for the last... this last week we had to endure the worst kind of racism and that too in the lab. This is how it began. Till the week before we had been using a kind of mice called C57/BL6. This week onwards we shifted to BAL B/C mice. And that's where the trouble began! For two days in a row we couldn't manage to get a single electrical recording despite trying from 10AM to 6PM! It just would not respond. And the only difference was this... the former were Black mice and these new ones were White! :p But yes we did finally get the better of them today and put them into place. Infact, we managed to get two of our most impressive recordings till date! :)
Thats all for now... this letter has turned out to be much longer than I had planned..... so till the next fortnightly update... Adios!
Cheers,
Shailesh Appukuttan

